The Effect of Erythromycin on Occurrence of Leaks From Cervical Esophageal-Gastric Anastomosis After Trans-Hiatal Esophagectomy

Summary

Cervical anastomotic leak is one of the most common complications after trans-hiatal esophagectomy. Hypothesis: An early post operative administration of a pro-kinetic dosage of erythromycin will reduce leak occurrence. Design: This is a prospective, randomized, double blind, placebo controlled study. Number of patients: 30. Inclusion Criteria: * Patients after trans-hiatal esophagectomy Exclusion Criteria: * Allergy to erythromycin * Use of phenothiazine * QT prolongation * Liver function test (LFT) abnormalities * Myasthenia gravis * Cardiomyopathy

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