Effect on Weight Loss of Exenatide Versus Placebo

Summary

This trial is designed to compare the effects of twice-daily exenatide and twice-daily placebo on weight loss. This trial will evaluate overweight and obese subjects with type 2 diabetes who have inadequate glycemic control with metformin, sulfonylurea, or metformin plus a sulfonylurea. Subjects will be treated with exenatide or placebo in addition to their current oral antidiabetes agent regimen and participate in a lifestyle modification program.

Timeline

Start

2006-09

Primary completion

2008-02

Completion

2008-02

Outcome

Met primary endpoint

registry analysis (superiority or other test); Group A (Exenatide) vs Group B (Placebo); p = 0.0030; Mixed Model Repeated Measures NCT00375492 ↗

Publications

• Pencek R, Blickensderfer A, Li Y, Brunell SC, Anderson PW. Exenatide twice daily: analysis of effectiveness and safety data stratified by age, sex, race, duration of diabetes, and body mass index. Postgrad Med. 2012 Jul;124(4):21-32. doi: 10.3810/pgm.2012.07.2567.

Drugs

Indications