Nicotine as an Adjuvant Analgesic for Third Molar Surgery

Summary

Third molar surgery is complicated by pain and swelling for several days after surgery. Non-steroidal antiinflammatory drugs have been useful in combination with opioids for treatment. Nicotine has antiinflammatory and pain relieving properties. We will use nicotine or placebo as a nasal spray before surgery to determine whether nicotine affects pain or inflammation.

Timeline

Start

2004-07

Primary completion

2009-05

Completion

2009-06

Drugs

Indications