Gabapentin Treatment of Alcohol Dependence

Summary

Gabapentin treatment for alcohol dependence

Timeline

Start

2004-02

Primary completion

2009-07

Completion

2010-02

Outcome

Met primary endpoint

paper Gabapentin significantly improved the rates of abstinence and no heavy drinking. PMID 24190578 ↗

paper 30.1%) in the 1800-mg group (P = .04 for linear dose effect; number needed to treat [NNT] = 8 for 1800 mg). PMID 24190578 ↗

paper 58.8%) in the 1800-mg group (P = .02 for linear dose effect; NNT = 5 for 1800 mg). PMID 24190578 ↗

Publications

• Results Mason BJ, Quello S, Goodell V, Shadan F, Kyle M, Begovic A. Gabapentin treatment for alcohol dependence: a randomized clinical trial. JAMA Intern Med. 2014 Jan;174(1):70-7. doi: 10.1001/jamainternmed.2013.11950.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Gabapentin	Unknown	900 mg	Oral
Subject	Gabapentin	Unknown	1800 mg	Oral

Indications