Human Brain Natriuretic Peptide (BNP) (or Nesiritide) to Help Heart, Kidney and Humoral Function.

Phase 1/2 Completed 41 enrolled Mayo Clinic National Center for Research Resources (NCRR) · collab National Heart, Lung, and Blood Institute (NHLBI) · collab National Institutes of Health (NIH) · collab Scios, Inc. · collab

RandomizedParallel-groupTriple-blindBasic science

Summary

The purpose of this research study is to evaluate the effects of cardiac hormone replacement with SQ (subcutaneous or under the skin) injection of BNP (brain natriuretic peptide, a hormone produced by the heart) on the pumping ability of the heart, kidney function and levels of different hormones in the blood in response to an intravenous salt solution.

Timeline

Start: 2008-03
Primary completion: 2011-04
Completion: 2012-08

Publications

Wan SH, McKie PM, Schirger JA, Slusser JP, Hodge DO, Redfield MM, Burnett JC Jr, Chen HH. Chronic Peptide Therapy With B-Type Natriuretic Peptide in Patients With Pre-Clinical Diastolic Dysfunction (Stage B Heart Failure). JACC Heart Fail. 2016 Jul;4(7):539-547. doi: 10.1016/j.jchf.2015.12.014. Epub 2016 Feb 10.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	BNP	Peptide	10 ug/kg	Subcutaneous

Human Brain Natriuretic Peptide (BNP) (or Nesiritide) to Help Heart, Kidney and Humoral Function.

Summary

Timeline

Publications

Drugs

Indications