drugset / Trial / NCT00407693
PET Whole Body Imaging Using a Peripheral Benzodiazepine Receptor Ligand [C-11]PBR28
Non-randomizedSingle-groupOpen-labelDiagnostic
Summary
In this study we will examine where the radioactive tracer \[11C\]PBR28 is distributed in the body of healthy volunteers to calculate the radiation exposure to organs of the body. We will also test if \[11C\]PBR28 binds to your blood cells and compare with the binding in PET images.
Timeline
- Start
- 2006-11-28
- Primary completion
- —
- Completion
- 2016-07-21
Publications
- Background Anholt RR, De Souza EB, Oster-Granite ML, Snyder SH. Peripheral-type benzodiazepine receptors: autoradiographic localization in whole-body sections of neonatal rats. J Pharmacol Exp Ther. 1985 May;233(2):517-26.
- Background Anholt RR, Murphy KM, Mack GE, Snyder SH. Peripheral-type benzodiazepine receptors in the central nervous system: localization to olfactory nerves. J Neurosci. 1984 Feb;4(2):593-603. doi: 10.1523/JNEUROSCI.04-02-00593.1984.
- Background Anholt RR, Pedersen PL, De Souza EB, Snyder SH. The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane. J Biol Chem. 1986 Jan 15;261(2):576-83.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | PBR28 | Diagnostic / imaging agent | — | — |
Indications
No indication recorded.