High Density Lipoprotein Turnover

Summary

The objective of the study is to evaluate the effect of Rimonabant 20mg in comparison to placebo, on HDL and VLDL lipoprotein kinetics, over a 12 months period. Primary objectives: * To assess effect of Rimonabant on HDL ApoA-I fractional catabolic rate (FCR). Secondary objectives: * To assess effect of Rimonabant on HDL ApoA-I production rate (PR) and on other lipoprotein kinetics. * To assess effect of Rimonabant on lipids, glycemic and inflammatory parameters * To assess effect of Rimonabant on body composition * To assess safety of Rimonabant

Timeline

Start

2006-10

Primary completion

2008-12

Completion

2008-12

Publications

• Verges B, Adiels M, Boren J, Barrett PH, Watts GF, Chan D, Duvillard L, Soderlund S, Matikainen N, Kahri J, Robin I, Taskinen MR. Interrelationships between the kinetics of VLDL subspecies and HDL catabolism in abdominal obesity: a multicenter tracer kinetic study. J Clin Endocrinol Metab. 2014 Nov;99(11):4281-90. doi: 10.1210/jc.2014-2365. Epub 2014 Jul 31.

Drugs

Indications