drugset / Trial / NCT00409318
Study of TNF-Antagonism in Metabolic Syndrome
RandomizedParallel-groupQuadruple-blindTreatment
Summary
This study investigates whether blockade of TNF will result in reduced inflammatory indices in patients with the metabolic syndrome
Timeline
- Start
- 2004-04
- Primary completion
- 2005-05
- Completion
- 2005-05
Publications
- Results Bernstein LE, Berry J, Kim S, Canavan B, Grinspoon SK. Effects of etanercept in patients with the metabolic syndrome. Arch Intern Med. 2006 Apr 24;166(8):902-8. doi: 10.1001/archinte.166.8.902.
- Zanni MV, Stanley TL, Makimura H, Chen CY, Grinspoon SK. Effects of TNF-alpha antagonism on E-selectin in obese subjects with metabolic dysregulation. Clin Endocrinol (Oxf). 2010 Jul;73(1):48-54. doi: 10.1111/j.1365-2265.2009.03741.x.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Etanercept | Protein / enzyme biologic | 50 mg | Subcutaneous |