Safety and Pharmacokinetic Effects of Oseltamivir Alone or in Combination With Amantadine

Phase 1 Completed 18 enrolled Novartis Hoffmann-La Roche · collab

RandomizedCrossoverOpen-labelTreatment

Summary

This study is designed to assess the safety and pharmacokinetic effects of oseltamivir administration alone or in combination with amantadine in healthy volunteers.

Timeline

Start: 2006-08
Primary completion: —
Completion: 2006-12

Publications

Morrison D, Roy S, Rayner C, Amer A, Howard D, Smith JR, Evans TG. A randomized, crossover study to evaluate the pharmacokinetics of amantadine and oseltamivir administered alone and in combination. PLoS One. 2007 Dec 12;2(12):e1305. doi: 10.1371/journal.pone.0001305.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Amantadine	Unknown	100 mg	Oral
Subject	Oseltamivir	Small molecule	75 mg	Oral

Indications

No indication recorded.