drugset / Trial / NCT00421811
A Study of ADH-1 in Combination With Normothermic Isolated Limb Infusion of Melphalan
Non-randomizedParallel-groupOpen-labelTreatment
Summary
N-cadherin, a protein involved in blood vessel cell binding and on the surface of many tumor cells, is increased as cancer progresses. ADH-1 blocks N-cadherin. This study will test the safety and effects of the combination ADH-1 with Normothermic Isolated Limb Infusion of Melphalan in subjects with locally advanced malignant melanoma.
Timeline
- Start
- 2007-04
- Primary completion
- 2009-03
- Completion
- 2009-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | ADH-1 | Protein / enzyme biologic | 4 g | Intravenous |
| Subject | Melphalan | Small molecule | 0.0075 mg/ml | Other |
| Subject | Melphalan | Small molecule | 0.01 mg/ml | Other |