Measuring Placebo Effect by Elimination and Investigating Mechanism of Action

Completed 180 enrolled King Faisal Specialist Hospital & Research Center King AbdulAziz City for Science and Technology · collab

RandomizedCrossoverTriple-blindTreatment

Summary

We propose to measure the effect of placebo by elimination as well as by a "balanced placebo" design, determine its interaction with active drug, and explore whether placebo exerts part of its effect at the pharmacokinetics level.

Timeline

Start: 2007-01
Primary completion: 2009-02
Completion: 2009-02

Publications

Hammami MM, Al-Gaai EA, Alvi S, Hammami MB. Interaction between drug and placebo effects: a cross-over balanced placebo design trial. Trials. 2010 Nov 19;11:110. doi: 10.1186/1745-6215-11-110.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Caffeine	Small molecule	300 mg	—

Indications

No indication recorded.