Comparison of 2L NRL994 With NaP Preparation in Colon Cleansing Prior to Colonoscopies for Colon Tumor Screening

Summary

To compare the efficacy, acceptability and safety of the new 2 liter gut cleansing solution (Moviprep) and NaP preparation in routine colon cleansing prior to tumor screening colonoscopies

Timeline

Start

2004-09

Primary completion

—

Completion

2005-05

Outcome

Met primary endpoint

paper Successful bowel cleansing rate was significantly higher in the PEG+Asc PMID 25180609 ↗

paper PEG+Asc 93.4% [95% CI 89.5-96.2] versus NaP 22.8% [15.5-31.6%], p < 0.0001 PMID 25180609 ↗

Publications

• Results Ell C, Fischbach W, Layer P, Boehm G, Bokemeyer B, Frick B, et al. Polyethylene Glycol with electrolytes and ascorbic acid versus sodium phosphate for bowel cleansing before coloscopy for cancer screening: a randomised, controlled trial. Endoscopy 2006; 38 (Suppl II): A18
• Ell C, Fischbach W, Layer P, Halphen M. Randomized, controlled trial of 2 L polyethylene glycol plus ascorbate components versus sodium phosphate for bowel cleansing prior to colonoscopy for cancer screening. Curr Med Res Opin. 2014 Dec;30(12):2493-503. doi: 10.1185/03007995.2014.960513. Epub 2014 Sep 23.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Moviprep	Other / unclassified	2000 ml	Oral
Comparator	sodium phosphate	Unknown	45 ml	Oral

Indications

No indication recorded.