drugset / Trial / NCT00428844
Study of Daptomycin in Subjects Undergoing Surgery for Osteomyelitis Associated With an Infected Prosthetic Caused by Staphylococci
RandomizedParallel-groupOpen-labelTreatment
Summary
This is a research study designed to look at the efficacy and safety of daptomycin given at a dose of 6 mg/kg or 8 mg/kg in subjects being treated for prosthetic hip or knee infections caused by Staphylococci. These types of bacteria are among the most common types of bacteria causing infections of prosthetic joints.
Timeline
- Start
- 2007-06-26
- Primary completion
- 2010-03-26
- Completion
- 2010-06-23
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Daptomycin | Other / unclassified | 6 mg/kg | Intravenous |
| Subject | Daptomycin | Other / unclassified | 8 mg/kg | Intravenous |
| Comparator | FLOXACILLIN | Small molecule | 1 mg | — |
| Comparator | FLOXACILLIN | Small molecule | 2 mg | — |
| Comparator | Teicoplanin | Other / unclassified | 6 mg/kg | — |
| Comparator | Vancomycin | Other / unclassified | 1 g | — |
| Comparator | nafcillin | Small molecule | 1 g | — |
| Comparator | nafcillin | Small molecule | 2 g | — |
| Comparator | oxacillin | Small molecule | 1 g | — |
| Comparator | oxacillin | Small molecule | 2 g | — |