Juvista (Avotermin) in Scars Following Varicose Vein Removal

Phase 2 Completed 156 enrolled Renovo ICON Clinical Research · collab

RandomizedSingle-groupTriple-blindPrevention

Summary

This trial is being undertaken to investigate the efficacy and safety of Juvista in the improvement of scar appearance when administered to approximated wound margins following varicose vein surgery. The results from this trial will be used to select doses for investigation in future clinical trials with the compound.

Timeline

Start: 2006-11
Primary completion: 2009-01
Completion: 2009-04

Publications

McCollum PT, Bush JA, James G, Mason T, O'Kane S, McCollum C, Krievins D, Shiralkar S, Ferguson MW. Randomized phase II clinical trial of avotermin versus placebo for scar improvement. Br J Surg. 2011 Jul;98(7):925-34. doi: 10.1002/bjs.7438. Epub 2011 Mar 29.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Avotermin	Protein / enzyme biologic	5 ng	Other
Subject	Avotermin	Protein / enzyme biologic	50 ng	Other
Subject	Avotermin	Protein / enzyme biologic	200 ng	Other
Subject	Avotermin	Protein / enzyme biologic	500 ng	Other

Juvista (Avotermin) in Scars Following Varicose Vein Removal

Summary

Timeline

Publications

Drugs

Indications