Use of the Combination of Olmesartan and Hydrochlorothiazide in Essential Hypertension

Phase 3 Completed 972 enrolled Daiichi Sankyo Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

The study will evaluate the blood pressure lowering effects of two different dosages of the combination of olmesartan and hydrochlorothiazide in patients with moderate or severe high blood pressure.

Timeline

Start: 2007-02
Primary completion: 2008-03
Completion: 2008-05

Outcome

Met primary endpoint

registry analysis (superiority or other test); OM/HCTZ 40/25mg + 20/12.5 Matching Placebo vs OM/HCTZ 40/0mg + 20/12.5 Matching Placebo; p <0.0001 NCT00430508 ↗

Publications

Rosenbaum D, Girerd X. Olmesartan medoxomil combined with hydrochlorothiazide improves 24-hour blood pressure control in moderate-to-severe hypertension. Curr Med Res Opin. 2012 Feb;28(2):179-86. doi: 10.1185/03007995.2011.644626. Epub 2012 Jan 9.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Hydrochlorothiazide	Unknown	12.5 mg	—
Subject	Hydrochlorothiazide	Unknown	25 mg	—
Subject	Olmesartan medoxomil	Unknown	20 mg	—
Subject	Olmesartan medoxomil	Unknown	40 mg	—