drugset / Trial / NCT00440830
Nicotine Patch as an Analgesic Adjuvant After Surgery
RandomizedParallel-groupQuadruple-blindTreatment
Summary
Effect of nicotine patch as an adjutant for acute pain after surgery.
Timeline
- Start
- 2005-12
- Primary completion
- 2008-12
- Completion
- 2008-12
Outcome
Missed primary endpoint
paper Patients treated with nicotine reported higher pain scores than those treated with placebo over the first hour after surgery (P < 0.01, average numerical rating scale increase = 0.67) PMID 19923530 ↗
paper and there was no difference between groups in the subsequent 5 days (P > 0.05). PMID 19923530 ↗
Publications
- Results Olson LC, Hong D, Conell-Price JS, Cheng S, Flood P. A transdermal nicotine patch is not effective for postoperative pain management in smokers: a pilot dose-ranging study. Anesth Analg. 2009 Dec;109(6):1987-91. doi: 10.1213/ANE.0b013e3181bd1612.
- Results Hong D, Conell-Price J, Cheng S, Flood P. Transdermal nicotine patch for postoperative pain management: a pilot dose-ranging study. Anesth Analg. 2008 Sep;107(3):1005-10. doi: 10.1213/ane.0b013e318163204f.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Nicotine | Unknown | 5 mg | Other |
| Subject | Nicotine | Unknown | 10 mg | Other |
| Subject | Nicotine | Unknown | 15 mg | Other |
Indications
No indication recorded.