A Randomized Trial of Early Discharge After Trans-radial Stenting of Coronary Arteries in Acute MI and Rescue-PCI

Summary

* Abciximab administration is safe and reduces ischemic complications in patients undergoing rescue PCI after failed thrombolysis compared to placebo. * Abciximab improves angiographic scores and ventricular function after rescue-PCI compared to placebo. * Intracoronary abciximab administration is more effective than intravenous route of administration in terms of acute and mid-term angiographic and clinical results. * Intracoronary and intravenous bolus administration of abciximab dose provides similar platelet aggregation inhibition (PAI). * There is a significant relationship between PAI after abciximab administration and indexes of myocardial perfusion. * Routine use of Sirolimus-eluting stents (Cypher, Cordis, US) in rescue-PCI is associated with a low rate of target vessel revascularization. * Cardiac MRI early and late after rescue-PCI provides detailed information on myocardial injury and irreversible necrosis, which are correlated with angiographic perfusion scores. * After uncomplicated trans-radial rescue PCI, patients can be retransferred early to their referring center.

Timeline

Start

2007-02

Primary completion

2012-10

Completion

2013-05

Drugs

Indications