drugset / Trial / NCT00444106
Evaluation of Potential Effect of Artemether - Lumefantrine and Malaria Drugs on Auditory Function
RandomizedParallel-groupOpen-labelTreatment
Summary
To evaluate the potential effects of artemether- lumefantrine on the auditory function
Timeline
- Start
- 2007-05
- Primary completion
- 2008-11
- Completion
- 2008-11
Outcome
Met primary endpoint
registry NUMBER Artemether-lumefantrine (Coartem): 2.6 (0.7 to 6.6) Percentage of Participants NCT00444106 ↗
registry Artemether-lumefantrine (Coartem); p <.0001; One-sided exact test for a single propn. NCT00444106 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Artemether | Small molecule | 20 mg | Oral |
| Comparator | Artesunate | Small molecule | 4 mg/kg | Oral |
| Comparator | Artesunate | Small molecule | 50 mg | Oral |
| Comparator | Atovaquone | Small molecule | 250 mg | Oral |
| Comparator | Mefloquine | Unknown | 25 mg/kg | Oral |
| Comparator | Mefloquine | Unknown | 250 mg | Oral |
| Comparator | Proguanil | Small molecule | 100 mg | Oral |
| Subject | lumefantrine | Small molecule | 120 mg | Oral |