drugset / Trial / NCT00449280
Drug Interaction Study of Sorafenib and Rapamycin in Advanced Malignancies
RandomizedParallel-groupOpen-labelTreatment
Summary
The goal of this study is to determine whether a significant pharmacokinetic interaction exists between rapamycin and sorafenib. This study will also look at the toxicity of the combination of rapamycin and sorafenib and the antitumor activity of the combination in subjects with advanced cancers.
Timeline
- Start
- 2006-11
- Primary completion
- 2009-06
- Completion
- 2009-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Sirolimus | Small molecule | 3 mg | — |
| Subject | Sirolimus | Small molecule | 30 mg | — |
| Subject | Sorafenib | Small molecule | 200 mg | — |