Effect of Parecoxib on Post-craniotomy Pain

Phase 4 Completed 130 enrolled Melbourne Health

RandomizedParallel-groupDouble-blindTreatment

Summary

Aim of this trial: To investigate whether post-craniotomy analgesia with (i) intravenous (IV) parecoxib plus intravenous paracetamol is superior to (ii) intravenous paracetamol alone. Study Hypothesis: Post-operative analgesia with intravenous parecoxib in combination with intravenous paracetamol will be superior to intravenous paracetamol alone.

Timeline

Start: 2006-09
Primary completion: 2008-12
Completion: 2008-12

Publications

Williams DL, Pemberton E, Leslie K. Effect of intravenous parecoxib on post-craniotomy pain. Br J Anaesth. 2011 Sep;107(3):398-403. doi: 10.1093/bja/aer223.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Parecoxib	Small molecule	40 mg	Intravenous

Indications

No indication recorded.