Efficacy and Safety of Lacidipine and Amlodipine on Blood Pressure in Korean ISH Patients Aged 60 to 80 Years

Summary

Primary Objective -To investigate the clinical effectiveness of lacidipine and amlodipine on systolic blood pressure (SBP) in Korean ISH patients aged 60 to 80 years. Secondary Objectives -To investigate the clinical effectiveness of lacidipine and amlodipine on diastolic blood pressure (DBP) in Korean ISH patients aged 60 to 80 years To demonstrate the effectiveness of lacidipine and amlodipine on endothelial function through measurement of markers of inflammation.

Timeline

Start

2007-01

Primary completion

2009-07

Completion

2010-02

Publications

• Na JO, Seo HS, Choi CU, Lim HE, Kim JW, Kim EJ, Han SW, Rha SW, Park CG, Oh DJ; ELDER investigators. Results of a 14-Week, Multicenter, Prospective, Randomized, Open-Label, Noninferiority Clinical Trial Comparing the Antihypertensive Effect and Edema Incidence of Lacidipine and Amlodipine in Older Korean Patients with Mild-to-Moderate Hypertension. Curr Ther Res Clin Exp. 2013 Jun;74:54-61. doi: 10.1016/j.curtheres.2013.02.001.

Drugs

Indications