Half-Dose Depot Triptorelin Versus Reduced-Dose Daily Buserelin

NCT00461916 ↗

Phase 4 Completed 182 enrolled Tehran University of Medical Sciences

RandomizedParallel-groupDouble-blindTreatment

Summary

The purpose of this study is to determine whether half-dose depot triptorelin are as effective as reduced-dose daily buserelin in the controlled ovarian stimulation for intracytoplasmic sperm injection and embryo transfer

Timeline

Start: 2005-05
Primary completion: —
Completion: 2006-12

Outcome

Missed primary endpoint

paper No significant differences were seen in the mean (SD) number of follicles at HCG administration, as our primary outcome PMID 17635844 ↗

paper [10.3 (4.4) in Group I versus 11.1 (4.2) in Group II, P = 0.180 PMID 17635844 ↗

Publications

Safdarian L, Mohammadi FS, Alleyassin A, Aghahosseini M, Meysamie A, Rahimi E. Clinical outcome with half-dose depot triptorelin is the same as reduced-dose daily buserelin in a long protocol of controlled ovarian stimulation for ICSI/embryo transfer: a randomized double-blind clinical trial (NCT00461916). Hum Reprod. 2007 Sep;22(9):2449-54. doi: 10.1093/humrep/dem223. Epub 2007 Jul 17.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Triptorelin	Other / unclassified	1.87 mg	Intramuscular
Subject	buserelin	Unknown	0.25 mg	Subcutaneous