Tetracycline (Doxycycline) and Post Myocardial Infarction Remodeling

Summary

The aim of the study is to assess the efficacy of an antibiotic treatment with tetracycline (doxycycline) in the early stage of large reperfused acute myocardial infarction (AMI), in preventing left ventricular (LV) remodeling.

Timeline

Start

2007-05

Primary completion

2011-08

Completion

2011-08

Outcome

Met primary endpoint

paper The 6-month changes in %LVEDVi were significant smaller in the doxycycline group than in the control group [0.4% (IQR: -16.0 to 14.2%) vs.13.4% (IQR: PMID 24104875 ↗

paper 7.9 to 29.3%); P = 0.012], PMID 24104875 ↗

Publications

• Cerisano G, Buonamici P, Valenti R, Sciagra R, Raspanti S, Santini A, Carrabba N, Dovellini EV, Romito R, Pupi A, Colonna P, Antoniucci D. Early short-term doxycycline therapy in patients with acute myocardial infarction and left ventricular dysfunction to prevent the ominous progression to adverse remodelling: the TIPTOP trial. Eur Heart J. 2014 Jan;35(3):184-91. doi: 10.1093/eurheartj/eht420. Epub 2013 Oct 8.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Doxycycline	Small molecule	100 mg	—

Indications