Vanderbilt Pertussis Exposure Study: PEP in Vaccinated Healthcare Workers Following Pertussis Exposure

Summary

The purpose of this study is to compare the effectiveness of two strategies of post-exposure prophylaxis (PEP) in healthcare workers (HCWs) who have been vaccinated with acellular pertussis vaccine and have been exposed to pertussis Secondary Objectives include a comparison of the costs of each PEP strategy and an assessment for risk factors associated with healthcare-associated acquisition of pertussis.

Timeline

Start

2007-05

Primary completion

2009-12

Completion

2009-12

Publications

• Goins WP, Edwards KM, Vnencak-Jones CL, Rock MT, Swift M, Thayer V, Schaffner W, Talbot TR. A comparison of 2 strategies to prevent infection following pertussis exposure in vaccinated healthcare personnel. Clin Infect Dis. 2012 Apr;54(7):938-45. doi: 10.1093/cid/cir973. Epub 2012 Jan 11.

Drugs

Indications