The Effects of Milk Proteins on Blood Pressure

Summary

The primary purpose of the study is to demonstrate a blood pressure lowering effect of CasiGold and CasiMax in subjects with high-normal blood pressure or mild hypertension. The secondary purpose is to collect human safety data after treatment with CasiGold and CasiMax, to gain insight into potential mechanisms by measurement of renin and angiotensin I and II, and to evaluate the genetic determinants of the individual BP lowering response by measurement of specific genetic polymorphisms.

Timeline

Start

2007-05-07

Primary completion

2007-12-18

Completion

2008-02

Outcome

Met primary endpoint

paper In subjects with stage 1 hypertension, MPH1 lowered systolic BP by 3.8 mm Hg (P = 0.0080) PMID 21059213 ↗

Publications

• Boelsma E, Kloek J. IPP-rich milk protein hydrolysate lowers blood pressure in subjects with stage 1 hypertension, a randomized controlled trial. Nutr J. 2010 Nov 8;9:52. doi: 10.1186/1475-2891-9-52.

Drugs

Indications