Study of Efficacy & Safety for 3 Infusion Regimens of IV Conivaptan in Subjects With Euvolemic or Hypervolemic Hyponatremia

Summary

The study is designed to assess the efficacy and safety of multiple infusions of conivaptan in subjects with euvolemic or hypervolemic hyponatremia

Timeline

Start

2007-04

Primary completion

2008-08

Completion

2008-08

Outcome

Met primary endpoint

registry Regimen 1 Conivaptan QD vs Regimen 3 Placebo; p = 0.019; ANCOVA NCT00478192 ↗

registry Regimen 2 Conivaptan BID vs Regimen 3 Placebo; p <0.001; ANCOVA NCT00478192 ↗

Publications

• Background Koren MJ, Hamad A, Klasen S, Abeyratne A, McNutt BE, Kalra S. Efficacy and safety of 30-minute infusions of conivaptan in euvolemic and hypervolemic hyponatremia. Am J Health Syst Pharm. 2011 May 1;68(9):818-27. doi: 10.2146/ajhp100260.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Conivaptan	Small molecule	20 mg	Intravenous

Indications

No indication recorded.