Artemisinin Resistance in Cambodia

Completed Medical University of Vienna Armed Forces Research Institute of Medical Sciences, Thailand · collab Global Emerging Infections Surveillance and Response System · collab National Center for Parasitology, Entomology and Malaria Control · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

The principal aim of this project is to investigate reports of developing artemisinin resistance in Cambodia using an integrated in vivo - in vitro approach to examine recent alarming reports of treatment failures with advanced combination therapies along the Thai-Cambodian border, which could have major impact on the malaria situation in the affected areas as well as the rest of the malaria-endemic world.

Timeline

Start: 2006-10
Primary completion: —
Completion: 2007-02

Publications

Noedl H, Se Y, Sriwichai S, Schaecher K, Teja-Isavadharm P, Smith B, Rutvisuttinunt W, Bethell D, Surasri S, Fukuda MM, Socheat D, Chan Thap L. Artemisinin resistance in Cambodia: a clinical trial designed to address an emerging problem in Southeast Asia. Clin Infect Dis. 2010 Dec 1;51(11):e82-9. doi: 10.1086/657120. Epub 2010 Oct 28.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Artesunate	Small molecule	200 mg	Oral

Artemisinin Resistance in Cambodia

Summary

Timeline

Publications

Drugs

Indications