Microcirculation Guided Therapy Versus "Standard Treatment" of Severe Sepsis

Summary

The purpose of this study is to asses the recovery of organ failure between two resuscitation protocols in severe sepsis: standard, pressure guided therapy versus a microcirculation guided therapy

Timeline

Start

2007-06

Primary completion

2008-12

Completion

—

Outcome

Missed primary endpoint

paper Per protocol, the decrease in SOFA score at day 4 was not different between groups (P = 0.64). PMID 25032942 ↗

Publications

• van der Voort PH, van Zanten M, Bosman RJ, van Stijn I, Wester JP, van Raalte R, Oudemans-van Straaten HM, Zandstra DF. Testing a conceptual model on early opening of the microcirculation in severe sepsis and septic shock: a randomised controlled pilot study. Eur J Anaesthesiol. 2015 Mar;32(3):189-98. doi: 10.1097/EJA.0000000000000126.

Drugs

Indications