Effect of Folic Acid on Endothelial and Baroreceptor Function in Patients With Heart Failure

Summary

The randomized, double-blind, placebo-controlled study aim to evaluate the effect of 1-month therapy with folic acid (5 mg/day) on endothelial function and baroreceptor function in patients with heart failure. Endothelial function will be studied non-invasively with flow-mediated dilation while for eveluating baroreceptor function sympathetic nervous system activity will be measured directly with microneurography in baseline condition and during infusion of sodium-nitroprusside.

Timeline

Start

2004-10

Primary completion

—

Completion

2007-05

Drugs

Indications