drugset / Trial / NCT00499811
Vorinostat in Treating Patients With Metastatic or Unresectable Solid Tumors or Lymphoma and Liver Dysfunction
NaSingle-groupOpen-labelTreatment
Summary
This phase I trial is studying the side effects and best dose of vorinostat in treating patients with metastatic or unresectable solid tumors or lymphoma and liver dysfunction. (closed for accrual as of 04/05/2010) Vorinostat may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Vorinostat may have different effects in patients who have changes in their liver function.
Timeline
- Start
- 2007-06
- Primary completion
- 2011-08
- Completion
- —
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Vorinostat | Small molecule | — | Oral |
Indications
Burkitt lymphoma
Hodgkins lymphoma
MALT lymphoma
Waldenstrom macroglobulinemia
adult T-cell leukemia/lymphoma
anaplastic large cell lymphoma
angioimmunoblastic T-cell lymphoma
chronic lymphocytic leukemia/small lymphocytic lymphoma
extranodal nasal NK/T cell lymphoma
grade III lymphomatoid granulomatosis
intraocular lymphoma
large-cell immunoblastic lymphoma
mantle cell lymphoma
mycosis fungoides and variants
nodal marginal zone B-cell lymphoma
primary central nervous system lymphoma
primary cutaneous B-cell lymphoma
small intestine lymphoma
splenic marginal zone lymphoma