A Study of Re-Treatment With MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to a Single Anti-TNF Inhibitor.

Summary

This single arm study will evaluate the efficacy and safety of repeated courses of MabThera in patients with active rheumatoid arthritis who have participated in ML19070, and have completed the week 24 visit. Eligible patients (DAS28 \>2.6 after week 24), will receive 2 infusions of 1g MabThera (Day 1 and day 15). For all patients in this extension study, up to 3 repeated courses of treatment are allowed. The anticipated time on study treatment is 1-2 years, and the target sample size is 100-500 individuals.

Timeline

Start

2007-07-23

Primary completion

2011-09-20

Completion

2011-09-20

Publications

• Dimanche A, Bervini D, Miller DR, Schar A, Goldberg J, Raabe A, Dunn AK. Cortical perfusion measurements with laser speckle contrast imaging during adenosine induced cardiac arrest for aneurysm clipping: a case report. Acta Neurochir (Wien). 2024 Jan 23;166(1):27. doi: 10.1007/s00701-024-05925-2.

Drugs

Indications