Safety and Efficacy of Palonosetron in Preventing Chemotherapy-induced Nausea and Vomiting

Phase 2 Completed 144 enrolled Hangzhou Jiuyuan Gene Engineering Co. Ltd. Sun Yat-sen University · collab Tigermed Consulting Co., Ltd · collab

RandomizedCrossoverQuadruple-blindSupportive care

Summary

The purpose of this study is to determine whether palonosetron is tolerate and effective in preventing chemotherapy-induced nausea and vomiting in oriental population. The study is comparing the safety and efficacy of palonosetron with granisetron, a frequently used antiemetic in China.

Timeline

Start: 2006-04
Primary completion: 2006-10
Completion: 2006-10

Publications

Tian W, Wang Z, Zhou J, Zhang S, Wang J, Chen Q, Huang C, Pan L, Zhang L, Huang J, Shen H, Lin T. Randomized, double-blind, crossover study of palonosetron compared with granisetron for the prevention of chemotherapy-induced nausea and vomiting in a Chinese population. Med Oncol. 2011 Mar;28(1):71-8. doi: 10.1007/s12032-009-9398-2. Epub 2010 Jan 5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Granisetron	Other / unclassified	3 mg	Intravenous
Subject	Palonosetron	Other / unclassified	0.25 mg	Intravenous

Indications

No indication recorded.