TBE Antibody Persistence and Booster Vaccination Study in Adults (Follow-up to Study 223)

Summary

The purpose of this study is to assess: * TBE antibody persistence 24, 34, 46 and 58 months (as applicable) after the first booster TBE vaccination with FSME-IMMUN 0.5ml given in Study 223, by means of ELISA (IMMUNOZYM FSME IgG) and Neutralization test (NT), * TBE antibody response to a second booster vaccination with FSME-IMMUN 0.5ml in the present study, by means of ELISA and NT, * Safety of FSME-IMMUN 0.5ml after the second booster vaccination.

Timeline

Start

2007-07

Primary completion

2010-07

Completion

2010-09

Publications

• Konior R, Brzostek J, Poellabauer EM, Jiang Q, Harper L, Erber W. Seropersistence of TBE virus antibodies 10 years after first booster vaccination and response to a second booster vaccination with FSME-IMMUN 0.5mL in adults. Vaccine. 2017 Jun 16;35(28):3607-3613. doi: 10.1016/j.vaccine.2017.03.059. Epub 2017 May 22.

Drugs

Indications