Trial of Montelukast in Eosinophilic Esophagitis

Summary

Evaluate clinical effectiveness of oral montelukast compared to placebo on prevention of dysphagia and food impaction in patients with EE. Also evaluate tolerance and safety of oral montelukast in treatment of EE.

Timeline

Start

2007-08

Primary completion

2015-09

Completion

2015-09

Outcome

Missed primary endpoint

paper 40% of patients remained in remission, but this proportion did not differ significantly from that of the placebo group. PMID 27650328 ↗

Publications

• Alexander JA, Ravi K, Enders FT, Geno DM, Kryzer LA, Mara KC, Smyrk TC, Katzka DA. Montelukast Does not Maintain Symptom Remission After Topical Steroid Therapy for Eosinophilic Esophagitis. Clin Gastroenterol Hepatol. 2017 Feb;15(2):214-221.e2. doi: 10.1016/j.cgh.2016.09.013. Epub 2016 Sep 17.

Drugs

Indications