Safety Study of Vitamin K2 During Anticoagulation in Human Volunteers

Summary

Oral anticoagulants that are widely used for the treatment of thrombo-embolic disease exert their effect by blocking the recycling of vitamin K. Vitamin K acts as a co-factor in the posttranslational carboxylation of vitamin K-dependent proteins such as osteocalcin and matrix-gla protein. It is important to quantify the dose-response relationship of the interaction between vitamin K and oral anticoagulants and to investigate at what dosage vitamin K will interfere with oral anticoagulants in a clinically relevant way.

Timeline

Start

2007-09

Primary completion

2007-12

Completion

2007-12

Drugs

Indications

No indication recorded.