Effectiveness of Arginine as a Treatment for Sickle Cell Anemia

Phase 2 Completed 128 enrolled UCSF Benioff Children's Hospital Oakland National Heart, Lung, and Blood Institute (NHLBI) · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

Sickle cell disease (SCD), also known as sickle cell anemia, is an inherited genetic disease that can cause intense pain episodes. This study will evaluate the effectiveness of the nutritional supplement arginine at improving blood cell function and disease symptoms in people with SCD.

Timeline

Start: 2004-06
Primary completion: 2007-09
Completion: 2008-01

Publications

Bolarinwa AB, Oduwole O, Okebe J, Ogbenna AA, Otokiti OE, Olatinwo AT. Antioxidant supplementation for sickle cell disease. Cochrane Database Syst Rev. 2024 May 22;5(5):CD013590. doi: 10.1002/14651858.CD013590.pub2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	L-arginine	Small molecule	0.05 g/kg	—
Comparator	L-arginine	Small molecule	0.1 g/kg	—

Effectiveness of Arginine as a Treatment for Sickle Cell Anemia

Summary

Timeline

Publications

Drugs

Indications