drugset / Trial / NCT00516282
VNP40101M and Temozolomide in Treating Patients With Progressive or Relapsed Malignant Glioma
NaSingle-groupOpen-labelTreatment
Summary
RATIONALE: Drugs used in chemotherapy, such as temozolomide and VNP40101M, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Temozolomide may also stop the growth of tumor cells by blocking blood flow to the tumor. PURPOSE: This phase I/II trial is studying the side effects and best dose of VNP40101M when given together with temozolomide and to see how well it works in treating patients with progressive or relapsed malignant glioma.
Timeline
- Start
- 2007-08
- Primary completion
- 2009-10
- Completion
- 2009-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Temozolomide | Small molecule | 75 mg/m2 | Oral |
| Subject | laromustine | Other / unclassified | 100 mg/m2 | Intravenous |
| Subject | laromustine | Other / unclassified | 125 mg/m2 | Intravenous |