Trial of Quetiapine in Anorexia Nervosa

Completed 21 enrolled University of California, San Diego University of South Florida · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

This research study is being held at UCSD to determine whether the medication Quetiapine helps people suffering from anorexia nervosa by reducing core eating disorders symptoms. This study will see if the medication Quetiapine helps symptoms of anxiety, depression, and obsessionality, in addition to increasing BMI. Men and women between the ages of 18-65 and are currently suffering from anorexia nervosa are needed.

Timeline

Start: 2006-07
Primary completion: 2010-05
Completion: 2010-05

Outcome

Missed primary endpoint

registry analysis (superiority test); Placebo vs Quetiapine; p = .72; t-test, 2 sided; note: t = .13 NCT00518973 ↗

paper There were no differences between drug and placebo in questionnaire scores, weight or measures of anxiety or depression. PMID 22535517 ↗

Publications

Results Powers PS, Klabunde M, Kaye W. Double-blind placebo-controlled trial of quetiapine in anorexia nervosa. Eur Eat Disord Rev. 2012 Jul;20(4):331-4. doi: 10.1002/erv.2169. Epub 2012 Apr 26.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Quetiapine	Small molecule	—	—