How Vitamin D Analogues Affect Endothelial Cells in Patients on Dialysis

Summary

Patients with chronic kidney disease and end stage renal disease have greater cardiovascular risk than the general population. Vitamin D analogues have been shown in observational studies to have mortality benefit for these patients. This study is designed to investigate doxercalciferol's effect on the vasculature (i.e. endothelial cell function) as a possible mechanism to explain the mortality benefit.

Timeline

Start

2007-09

Primary completion

2012-08

Completion

2012-08

Drugs

Indications