The Effect of Montelukast on Difficulty in Breathing After Exercise in Pediatric Patients (MK0476-377)(COMPLETED)

Summary

This study will see if there is a change in breathing after exercising when the child receives study drug ( montelukast or placebo). Breathing will be measured by a spirometer before exercising and measured again several times after exercising.

Timeline

Start

2008-02

Primary completion

2010-03

Completion

2010-03

Outcome

Met primary endpoint

paper significantly attenuated after single-dose montelukast compared with placebo (15.35% versus 20.00%; p = 0.020). PMID 22221440 ↗

Publications

• Wasfi YS, Kemp JP, Villaran C, Massaad R, Xin W, Smugar SS, Knorr BA, Philip G. Onset and duration of attenuation of exercise-induced bronchoconstriction in children by single-dose of montelukast. Allergy Asthma Proc. 2011 Nov-Dec;32(6):453-9. doi: 10.2500/aap.2011.32.3482.

Drugs

Indications