Pregabalin Versus Levetiracetam In Partial Seizures

Phase 3 Completed 509 enrolled Viatris Inc.

RandomizedParallel-groupTriple-blindTreatment

Summary

This study will compare pregabalin and levetiracetam in patients with partial seizures. It will also evaluate the safety and tolerability of pregabalin and levetiracetam in these patients.

Timeline

Start: 2007-10
Primary completion: 2012-05
Completion: 2012-05

Publications

Zaccara G, Almas M, Pitman V, Knapp L, Posner H. Efficacy and safety of pregabalin versus levetiracetam as adjunctive therapy in patients with partial seizures: a randomized, double-blind, noninferiority trial. Epilepsia. 2014 Jul;55(7):1048-57. doi: 10.1111/epi.12679. Epub 2014 Jun 5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Levetiracetam	Other / unclassified	1000 mg	Oral
Comparator	Levetiracetam	Other / unclassified	2000 mg	Oral
Comparator	Levetiracetam	Other / unclassified	3000 mg	Oral
Comparator	Pregabalin	Small molecule	300 mg	Oral
Comparator	Pregabalin	Small molecule	450 mg	Oral
Comparator	Pregabalin	Small molecule	600 mg	Oral

Pregabalin Versus Levetiracetam In Partial Seizures

Summary

Timeline

Publications

Drugs

Indications