Treatment of Binge Eating in Obese Patients in Primary Care
Summary
This study will test the effectiveness of two empirically-supported but distinct treatments for recurrent binge eating in obese patients: 1) Cognitive Behavior Therapy, using a pure self-help approach and 2) sibutramine, an anti-obesity medication also found to have efficacy for binge eating. Self-help Cognitive Behavior Therapy and sibutramine will be administered alone and in combination in a primary care setting.
Timeline
- Start
- 2007-09
- Primary completion
- 2012-10
- Completion
- 2012-10
Outcome
Missed primary endpoint
registry analysis (unspecified test); Sibutramine vs Placebo vs Placebo/CBTsh vs Sibutramine/CBTsh; p = 0.60; Chi-squared NCT00537810 ↗
registry analysis (unspecified test); Sibutramine vs Placebo vs Placebo/CBTsh vs Sibutramine/CBTsh; p = 0.13; Chi-squared NCT00537810 ↗
registry analysis (unspecified test); Sibutramine vs Placebo vs Placebo/CBTsh vs Sibutramine/CBTsh; p = 0.29; Chi-squared NCT00537810 ↗
Publications
- Results Grilo CM, Masheb RM, White MA, Gueorguieva R, Barnes RD, Walsh BT, McKenzie KC, Genao I, Garcia R. Treatment of binge eating disorder in racially and ethnically diverse obese patients in primary care: randomized placebo-controlled clinical trial of self-help and medication. Behav Res Ther. 2014 Jul;58:1-9. doi: 10.1016/j.brat.2014.04.002. Epub 2014 May 2.
- Correction to Grilo et al. (2015). J Consult Clin Psychol. 2015 Aug;83(4):747. doi: 10.1037/ccp0000043.
- Grilo CM, White MA, Masheb RM, Gueorguieva R. Predicting meaningful outcomes to medication and self-help treatments for binge-eating disorder in primary care: The significance of early rapid response. J Consult Clin Psychol. 2015 Apr;83(2):387-94. doi: 10.1037/a0038635. Epub 2015 Jan 26.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Sibutramine | Small molecule | 15 mg | — |