The Effect of Vitamin K2 on Bone Turnover

Summary

To investigate the effect of menatetrenone on bone turnover in postmenopausal patients with osteoporosis. One month of menatetrenone therapy enhanced the secretion and gamma-carboxylation of osteocalcin. Moderate increases of bone resorption and formation markers were observed after 6 months. These changes may contribute to fracture prevention in patients with osteoporosis.

Timeline

Start

2002-02-01

Primary completion

2013-01

Completion

2013-01

Drugs

Indications