Study the Safety and Effectiveness of Tadalafil on High Blood Pressure in the Blood Vessel Going From the Heart to the Lungs

Phase 3 Completed 357 enrolled Eli Lilly and Company ICOS Corporation · collab

Non-randomizedParallel-groupDouble-blindTreatment

Summary

Study to determine the long term safety of tadalafil in patients with increased blood pressure in the blood vessel that carries blood from the right heart to the lungs and to see if it will keep the disease from getting worse.

Timeline

Start: 2005-12
Primary completion: 2012-02
Completion: 2012-02

Publications

Oudiz RJ, Brundage BH, Galie N, Ghofrani HA, Simonneau G, Botros FT, Chan M, Beardsworth A, Barst RJ; PHIRST Study Group. Tadalafil for the treatment of pulmonary arterial hypertension: a double-blind 52-week uncontrolled extension study. J Am Coll Cardiol. 2012 Aug 21;60(8):768-74. doi: 10.1016/j.jacc.2012.05.004. Epub 2012 Jul 18.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Tadalafil	Small molecule	20 mg	Oral
Comparator	Tadalafil	Small molecule	40 mg	Oral

Study the Safety and Effectiveness of Tadalafil on High Blood Pressure in the Blood Vessel Going From the Heart to the Lungs

Summary

Timeline

Publications

Drugs

Indications