Pharmacokinetics of Ketamine in Infants and Children

Completed 21 enrolled Stanford University University of Colorado, Denver · collab

NaSingle-groupOpen-labelBasic science

Summary

Dosing of medications is based on the plasma level achieved with a given dose and how long the medicine remains in the body. This study is called pharmacokinetics-that is, what the body does to the medication. Ketamine is an intravenous medication used for anesthesia and sedation in children. However the pharmacokinetics of Ketamine has not been systematically studied. We propose to study the pharmacokinetics of ketamine in different age groups of children ranging from infants to teenagers.

Timeline

Start: 2007-07
Primary completion: 2009-01
Completion: 2009-01

Publications

Results Elkomy MH, Drover DR, Hammer GB, Galinkin JL, Ramamoorthy C. Population pharmacokinetics of ketamine in children with heart disease. Int J Pharm. 2015 Jan 15;478(1):223-231. doi: 10.1016/j.ijpharm.2014.11.026. Epub 2014 Nov 13.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ketamine	Small molecule	2 mg/kg	Intravenous

Indications

No indication recorded.