drugset / Trial / NCT00556205

Bevacizumab With or Without Sunitinib in Sunitinib-Refractory Renal Cell Carcinoma

NCT00556205

RandomizedCrossoverOpen-labelTreatment

Summary

The purpose of this research study is to further define an effective strategy for people with renal cell carcinoma and to learn the safety and effectiveness of two different types of sunitinib-refractory treatments: Bevacizumab alone or a combination of sunitinib and bevacizumab. Sunitinib is an FDA approved drug and is currently one of the standard treatments for advanced renal cell carcinoma. However, some people who receive this treatment do not respond to treatment or they stop responding to treatment. Bevacizumab is an FDA approved drug used for the treatment of several cancers however, is not yet approved for use in renal cell carcinoma.

Timeline

Start
2009-09
Primary completion
2009-09
Completion
2009-09

Drugs

EvaluationDrugModalityDoseRoute
Comparator Bevacizumab Monoclonal antibody 10 mg/kg Intravenous
Comparator Sunitinib Small molecule 50 mg Oral

Indications