Phase I/IIa Dose Ranging CHRONVAC-C® Study in Chronic HCV Patients

Summary

The purpose of this study is to evaluate if the DNA vaccine CHRONVAC-C® intended for future treatment of Hepatitis C infections is safe and tolerated when administered to HCV infected individuals with a low viral load. In addition the capability of the vaccine to induce an immune response and the effect on viral load will be studied. In order to increase the uptake of the vaccine the intra muscular injection is combined with electroporation, meaning that a brief electric field is applied to the injection site resulting in temporary pores in the cell membranes that allows the vaccine to enter the cells.

Timeline

Start

2007-10

Primary completion

2010-04

Completion

2010-04

Drugs

Indications