Evaluation of the Effect of Dextro-Amphetamin Added to Physiotherapy in Patients After Stroke

Summary

The aim of the study is to evaluate the effect of Dextro-amphetamin added to physiotherapy on motor recovery in patients after stroke. The study is a double-blinded placebo-controlled randomised controlled trial. Patients after a first-ever ischemic stroke will receive Dexamphetamine (10mg) twice per week for a duration of five weeks after a baseline phase of two weeks. The outcome measure focuses on motor recovery and will be assessed: * one and two weeks before study intervention (baseline phase) * five times during the study intervention * one week after study intervention (follow-up) * once after six and twelve months after start of the study intervention (follow-up).

Timeline

Start

2001-01

Primary completion

—

Completion

2006-09

Outcome

Met primary endpoint

Stopped: “Intended length of study ended”

paper Analysis of variance from baseline to 1 week follow-up revealed significant improvements in favor of EG for subscales ADL (P = .023) PMID 21712481 ↗

Publications

• Schuster C, Maunz G, Lutz K, Kischka U, Sturzenegger R, Ettlin T. Dexamphetamine improves upper extremity outcome during rehabilitation after stroke: a pilot randomized controlled trial. Neurorehabil Neural Repair. 2011 Oct;25(8):749-55. doi: 10.1177/1545968311405674. Epub 2011 Jun 28.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dextro-Amphetamin	Unknown	10 mg	Oral

Indications