Study of AzaSite Versus Vigamox Concentrations in the Conjunctiva and Aqueous Humor in Subjects Undergoing Routine Cataract Surgery

Phase 4 Completed 116 enrolled Merck Sharp & Dohme LLC

RandomizedParallel-groupOpen-labelSupportive care

Summary

The purpose of this study is to evaluate the drug concentrations in the conjunctiva and aqueous humor of AzaSite™ compared to Vigamox® in subjects undergoing routine cataract surgery

Timeline

Start: 2007-12
Primary completion: 2008-06
Completion: —

Publications

Stewart WC, Crean CS, Zink RC, Brubaker K, Haque RM, Hwang DG. Pharmacokinetics of azithromycin and moxifloxacin in human conjunctiva and aqueous humor during and after the approved dosing regimens. Am J Ophthalmol. 2010 Nov;150(5):744-751.e2. doi: 10.1016/j.ajo.2010.05.039. Epub 2010 Sep 1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Azithromycin	Small molecule	1 %	Other
Comparator	Moxifloxacin	Small molecule	0.5 %	Other

Study of AzaSite Versus Vigamox Concentrations in the Conjunctiva and Aqueous Humor in Subjects Undergoing Routine Cataract Surgery

Summary

Timeline

Publications

Drugs

Indications