drugset / Trial / NCT00582972
Does Omeprazole Decrease Intestinal Calcium Absorption?
Non-randomizedSingle-groupOpen-label
Summary
The purpose of this study is to measure the effect of omeprazole on intestinal calcium absorption in postmenopausal women.
Timeline
- Start
- 2008-01
- Primary completion
- 2008-12
- Completion
- 2010-12
Outcome
Missed primary endpoint
paper FCA (mean ± SD) was 20% ± 10% at visit 1, 18% ± 10% at visit 2, and 23% ± 10% following 30 ± 3 days of daily omeprazole (p = .07, ANOVA). PMID 20578215 ↗
paper PPI-associated hypochlorhydria does not decrease FCA following 30 days of continuous use. PMID 20578215 ↗
Publications
- Results Hansen KE, Jones AN, Lindstrom MJ, Davis LA, Ziegler TE, Penniston KL, Alvig AL, Shafer MM. Do proton pump inhibitors decrease calcium absorption? J Bone Miner Res. 2010 Dec;25(12):2786-95. doi: 10.1002/jbmr.166. Epub 2010 Jun 24.
- Results Jones AN, Shafer MM, Keuler NS, Crone EM, Hansen KE. Fasting and postprandial spot urine calcium-to-creatinine ratios do not detect hypercalciuria. Osteoporos Int. 2012 Feb;23(2):553-62. doi: 10.1007/s00198-011-1580-7. Epub 2011 Feb 24.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Omeprazole | Other / unclassified | 40 mg | Oral |